High Protein Italian Beef Pasta Bake

Featured in: Classic Family Dinners

This Italian-American inspired pasta bake combines lean ground beef with colorful vegetables including bell peppers, mushrooms, and fresh spinach, all tossed in a seasoned tomato sauce with whole wheat pasta. The dish comes together with a generous topping of melted mozzarella and Parmesan, creating that irresistible cheesy, bubbly finish. Modified for higher protein and lower calories, it delivers 33g of protein per serving while maintaining all the comfort food appeal. Perfect for meal prep, it reheats beautifully and keeps you satisfied for hours.

Updated on Wed, 21 Jan 2026 10:46:00 GMT
Golden bubbling mozzarella and Parmesan blanket the hearty High Protein Italian Beef and Pasta Bake, with turkey pepperoni peeking through.  Pin
Golden bubbling mozzarella and Parmesan blanket the hearty High Protein Italian Beef and Pasta Bake, with turkey pepperoni peeking through. | panpatriot.com

I first made this pasta bake on a Tuesday evening when meal prep fatigue had completely taken over. The kitchen was messy, I was tired, and somehow this bubbling dish with its pizza-inspired flavors ended up tasting like something from an Italian grandmother's kitchen. My roommate actually paused mid-bite to ask what restaurant I'd ordered from.

This became my go-to dish when I started training harder but refused to sacrifice satisfaction. My sister calls it gym food that doesn't taste like gym food, which might be the best compliment I've ever received. Now it's a Sunday staple, filling containers for the week ahead while making the whole apartment smell like an Italian restaurant.

Ingredients

  • Whole wheat pasta: The nutty flavor holds up beautifully to baking and adds fiber
  • Extra-lean ground beef: Brown it thoroughly and drain any excess fat for the best texture
  • Vegetables: The red pepper and mushrooms add sweetness and umami that balance the beef
  • Baby spinach: Stir it in at the end just until wilted so it doesn't become mushy
  • Crushed tomatoes and tomato paste: The paste concentration is what gives it that pizza sauce depth
  • Dried oregano and basil: Add them while the sauce simmers to wake up their essential oils
  • Part-skim mozzarella: Shred it yourself if you can for better melting
  • Turkey pepperoni: This optional addition somehow makes the whole dish taste like a pepperoni pizza

Instructions

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Get the oven ready:
Preheat to 200°C with the rack in the center position
Cook the pasta:
Boil until just al dente since it will continue cooking in the oven
Brown the beef:
Cook it in a large nonstick skillet until deeply browned, breaking it into small crumbles
Add the vegetables:
Sauté the onion, garlic, bell pepper and mushrooms until softened and fragrant
Wilt the spinach:
Stir it in for just one minute until it collapses into the mixture
Build the sauce:
Add the tomatoes, paste and herbs, then simmer for five minutes to meld the flavors
Combine everything:
Mix the pasta into the beef sauce until every piece is coated
Transfer to the baking dish:
Spread it evenly in a lightly greased 23x33 cm baking dish
Add the cheesy topping:
Sprinkle mozzarella and Parmesan across the surface, arranging pepperoni on top if using
Bake until bubbly:
Bake for 20 minutes until the cheese is melted and golden in spots
Garnish and serve:
Scatter fresh basil leaves on top for a pop of color and fresh flavor
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Easily open jars, bottles, and cans while cooking, making meal prep smoother and less frustrating.
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A close-up of the baked pasta dish shows its rich tomato sauce, whole wheat penne, and fresh basil garnish ready to serve.  Pin
A close-up of the baked pasta dish shows its rich tomato sauce, whole wheat penne, and fresh basil garnish ready to serve. | panpatriot.com

This pasta bake has seen me through finals weeks, post-workout hunger, and nights when friends dropped by unexpectedly. There's something incredibly reassuring about a dish that delivers this much satisfaction while actually supporting your goals.

Making It Your Own

I've discovered that swapping in chickpea pasta bumps the protein even higher while keeping the texture surprisingly close to traditional pasta. The first time I tried it, nobody noticed the difference until I mentioned it the next day.

Storage Secrets

This recipe was practically designed for meal prep. I portion it into glass containers while still slightly warm, then refrigerate for up to five days or freeze for those weeks when cooking feels impossible.

Serving Suggestions

A crisp green salad with a bright vinaigrette cuts through the richness perfectly. I also like serving it with roasted broccoli or steamed green beans for a complete meal that hits every nutritional note.

  • Try adding black olives for a salty punch
  • Roasted zucchini layers beautifully between the pasta
  • Red pepper flakes elevate the whole dish if you like heat
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Fresh basil leaves add a pop of green to the savory, pizza-inspired High Protein Italian Beef and Pasta Bake cooling on a countertop. Pin
Fresh basil leaves add a pop of green to the savory, pizza-inspired High Protein Italian Beef and Pasta Bake cooling on a countertop. | panpatriot.com

There's nothing quite like pulling this bubbling, golden-topped dish from the oven and watching everyone's eyes light up. Hope it becomes a staple in your kitchen too.

Recipe Questions

Can I freeze this pasta bake?

Yes, this freezes exceptionally well. Assemble the entire dish, wrap tightly in plastic and foil, and freeze for up to 3 months. Thaw overnight in the refrigerator before baking as directed.

What pasta shapes work best?

Penne or rotini are ideal because their ridges and curves hold the sauce well. Ziti, macaroni, or fusilli would also work nicely. Avoid long strands like spaghetti as they're difficult to eat in baked form.

Can I make this vegetarian?

Substitute the beef with plant-based ground crumbles or extra vegetables like zucchini, eggplant, and more mushrooms. You may want to add lentils or beans to maintain the protein content.

How do I know when it's done baking?

The dish is ready when the cheese is fully melted and beginning to bubble, and you can see the sauce bubbling up around the edges. This typically takes 20 minutes at 200°C (400°F).

Can I prepare this ahead of time?

Absolutely. Assemble everything up to 24 hours in advance, cover tightly, and refrigerate. You may need to add 5-10 minutes to the baking time if baking straight from the refrigerator.

What can I serve with this?

A crisp green salad with vinaigrette cuts through the richness beautifully. Garlic bread or roasted vegetables like broccoli or green beans also make excellent sides for a complete meal.

High Protein Italian Beef Pasta Bake

Hearty beef and vegetable pasta bake topped with melted cheese for a satisfying dinner.

Prep duration
20 min
Cooking duration
30 min
Total duration
50 min


Difficulty Easy

Origin Italian-American

Yield 6 Servings

Dietary requirements None specified

Ingredients

Pasta

01 10.5 oz whole wheat penne or rotini

Beef & Vegetables

01 1 lb extra-lean ground beef
02 1 medium onion, diced
03 2 cloves garlic, minced
04 1 red bell pepper, diced
05 3.5 oz mushrooms, sliced
06 3.5 oz baby spinach

Sauce

01 24 oz canned crushed tomatoes
02 2 tbsp tomato paste
03 1 tsp dried oregano
04 1 tsp dried basil
05 ½ tsp chili flakes
06 Salt and freshly ground black pepper, to taste

Cheese & Toppings

01 5 oz part-skim mozzarella cheese, shredded
02 1 oz grated Parmesan cheese
03 1 oz turkey pepperoni slices
04 Fresh basil, for garnish

Directions

Step 01

Preheat Oven: Preheat oven to 400°F.

Step 02

Cook Pasta: Cook pasta in a large pot of boiling salted water until al dente. Drain and set aside.

Step 03

Brown Ground Beef: In a large nonstick skillet over medium heat, cook the ground beef until browned, breaking it up as it cooks. Drain excess fat if needed.

Step 04

Sauté Vegetables: Add onion, garlic, bell pepper, and mushrooms to the skillet. Sauté for 5–7 minutes until softened.

Step 05

Add Spinach: Stir in spinach and cook until wilted, about 1 minute.

Step 06

Prepare Sauce: Add crushed tomatoes, tomato paste, oregano, basil, chili flakes, salt, and pepper. Simmer for 5 minutes, allowing flavors to meld.

Step 07

Combine Pasta and Sauce: Combine the cooked pasta with the beef and vegetable sauce mixture.

Step 08

Transfer to Baking Dish: Transfer the mixture to a lightly greased 9x13 inch baking dish.

Step 09

Add Cheese Topping: Sprinkle mozzarella and Parmesan evenly over the top. Arrange turkey pepperoni slices if using.

Step 10

Bake: Bake for 20 minutes, until cheese is melted and bubbly.

Step 11

Garnish and Serve: Garnish with fresh basil before serving, if desired.

Necessary tools

  • Large pot
  • Large nonstick skillet
  • 9x13 inch baking dish
  • Mixing spoon
  • Cheese grater

Allergy information

Review each ingredient for potential allergens and consult with healthcare providers if you're uncertain.
  • Contains wheat (pasta)
  • Contains milk (cheese, optional cottage/ricotta cheese)
  • May contain soy (check processed meat or cheese labels)

Nutrition facts (per portion)

These values are estimates only and shouldn't replace professional medical guidance.
  • Calories: 370
  • Fat: 11 g
  • Carbohydrates: 37 g
  • Protein: 33 g