Spicy Southern Cheesy Chicken

Featured in: Classic Family Dinners

This vibrant Southern-inspired casserole features tender chicken, al dente spaghetti, and a hearty layer of sharp cheddar cheese. Bell peppers and a dash of cayenne deliver the perfect spicy note, while a creamy base brings everything together. Prepared quickly, this comforting dish makes family dinners both easy and memorable. Top with green onions for an added burst of freshness, serve bubbling from the oven, and enjoy a meal that blends heartiness with bold flavor.

Updated on Mon, 06 Oct 2025 08:30:18 GMT
Spicy Southern Cheesy Chicken Spaghetti Casserole bubbling hot with golden cheddar and crisp bell peppers. Pin
Spicy Southern Cheesy Chicken Spaghetti Casserole bubbling hot with golden cheddar and crisp bell peppers. | panpatriot.com

Spicy Southern Cheesy Chicken Spaghetti Casserole brings bold flavor and South-inspired comfort to your table. This creamy, bubbly pasta bake is layered with juicy chicken, vibrant peppers, and loads of gooey sharp cheddar. It comes together quickly with simple prep and brings everyone together for seconds and thirds.

I made this the night we moved into a new home, and it instantly made things feel cozy and festive. Now, it is my go-to for family nights or when friends drop by. My family says it tastes better the next day, and every bite brings up stories from old Sunday dinners.

Ingredients

  • Boneless skinless chicken breasts: Choose fresh plump pieces with a light pink color for the juiciest shreds
  • Spaghetti: Choose standard or whole wheat spaghetti Cook until just al dente so it holds up in the bake
  • Shredded sharp cheddar cheese: Look for extra sharp for richer flavor Pre-shredded works but block cheese you shred yourself melts best
  • Fresh bell peppers: Pick a mix of red and green for sweetness plus color Choose firm and glossy peppers
  • Cream of chicken soup: Classic for creamy casseroles Opt for lower sodium if you prefer
  • Paprika: Smoked or sweet enhances warmth and depth
  • Cayenne pepper: Adds a spicy kick Start with less for milder flavor
  • Garlic powder: Brings a rounded savory base Use garlic granules if you like extra texture
  • Green onions: Adds fresh brightness at the end Use both green and white parts for best color and taste

Instructions

Prepare the Chicken:
Cook whole chicken breasts in a large pot over medium heat for about six to seven minutes on each side until deeply golden and cooked through to the center Shred using two forks once cooled
Boil the Spaghetti:
Fill a pot with water and a generous bit of salt Bring to a rolling boil Add spaghetti and cook until just al dente usually eight to ten minutes Drain well but do not rinse so the starch clings for creamier texture
Make the Base Mixture:
In a big bowl combine the shredded chicken cooked spaghetti cream of chicken soup diced bell peppers paprika cayenne pepper garlic powder and half the shredded cheddar Stir with a big spatula until everything is evenly coated and colorful
Fill the Casserole Dish:
Grease a large baking dish Transfer the cheesy chicken mixture smoothing it to the corners Sprinkle remaining cheese over the top for a gooey golden crust
Bake Until Bubbly:
Place the dish in a preheated oven at three hundred fifty degrees F Bake for twenty-five to thirty minutes until the cheese on top melts and bubbles Watch that the cheese browns but does not burn
Finish and Serve:
Allow to rest five minutes so the creamy sauce settles and sets Sprinkle with fresh green onions Cut into squares and serve while steamy
Close-up of Spicy Southern Cheesy Chicken Spaghetti Casserole fresh from the oven, topped with green onions. Pin
Close-up of Spicy Southern Cheesy Chicken Spaghetti Casserole fresh from the oven, topped with green onions. | panpatriot.com

The cheddar cheese is my favorite part Nothing beats the stretchy cheese pull over the creamy noodles and remembering the laughter around the table as everyone fights for the edges with the browned bits

Storage Tips

Store leftovers in a tight container in the fridge for up to four days For best texture let the casserole cool uncovered before sealing This keeps the topping from getting soggy Portion into single servings for easy, hearty lunches

Ingredient Substitutions

Swap cooked rotisserie chicken for a shortcut or use turkey for a leaner option Monterey Jack or Pepper Jack melts beautifully in place of cheddar Add mushrooms or swap out bell peppers for poblanos to change up the flavor

Serving Suggestions

Pair with a crisp side salad of baby greens or crunchy pickles for contrast Garlic bread rounds out the meal perfectly For a heat boost top servings with sliced jalapeños or drizzle of hot sauce at the table

Cultural and Historical Context

Southern casseroles grew popular for church gatherings and family reunions when everyone brought a signature dish This cheesy chicken spaghetti is a classic crowd-pleaser where comfort and pantry staples meet a bit of festive heat

Seasonal Adaptations

Use roasted corn and diced tomatoes in summer for freshness Swap in roasted butternut squash or poblano chilies in fall Substitute leftover turkey and cranberries for a wintry holiday twist

Success Stories

We made this after a chilly soccer game and the whole pan vanished that night Several friends have adopted it as their own cold-weather tradition It’s a sure bet when you want something that feels like a Southern hug from the oven

Freezer Meal Conversion

Assemble all components in a freezer-safe dish before baking Wrap tightly and freeze for up to two months Thaw overnight and bake as usual adding a few extra minutes until bubbly and hot

Serving of Spicy Southern Cheesy Chicken Spaghetti Casserole featuring creamy layers and a spicy, gooey cheese topping. Pin
Serving of Spicy Southern Cheesy Chicken Spaghetti Casserole featuring creamy layers and a spicy, gooey cheese topping. | panpatriot.com

Serve bubbling hot and gather everyone around for the cheesiest bites This casserole promises comfort in every forkful

Recipe Questions

Can I prepare this casserole ahead of time?

Yes, you can assemble the casserole in advance, cover, and refrigerate. Bake when ready to serve for best results.

What cheeses work besides sharp cheddar?

Monterey Jack, mozzarella, or pepper jack can be used for a creamier or spicier flavor profile.

Are there substitute proteins for chicken?

Cooked turkey, rotisserie chicken, or plant-based chicken substitutes are all suitable alternatives.

How can I adjust the spice level?

Reduce or increase cayenne pepper to suit your taste. Omit for a milder result or add jalapeños for extra heat.

Can I freeze leftovers?

Yes, cool completely before transferring to an airtight container. Freeze for up to 3 months and reheat thoroughly to serve.

Spicy Southern Cheesy Chicken

Creamy, cheesy chicken spaghetti with a Southern kick and zesty peppers, perfect for family meals or cozy dinners.

Prep duration
15 min
Cooking duration
30 min
Total duration
45 min


Difficulty Medium

Origin Southern American

Yield 8 Servings

Dietary requirements None specified

Ingredients

Main Ingredients

01 3 to 4 boneless, skinless chicken breasts (approximately 1.5 pounds)
02 8 ounces dried spaghetti
03 2 cups shredded sharp cheddar cheese
04 1 cup chopped fresh bell peppers
05 1 can (10.5 ounces) condensed cream of chicken soup
06 1 teaspoon paprika
07 1/2 teaspoon cayenne pepper
08 1 teaspoon garlic powder
09 1/4 cup sliced green onions

Directions

Step 01

Prepare for Baking: Preheat oven to 350°F (175°C) and generously grease a large casserole dish.

Step 02

Cook Chicken: In a large pot over medium heat, sear chicken breasts for 6–7 minutes per side until golden brown and fully cooked. Remove from heat and shred the chicken using forks.

Step 03

Boil Pasta: Bring a large pot of salted water to a boil and cook spaghetti for 8–10 minutes until al dente. Drain thoroughly and set aside.

Step 04

Combine Ingredients: In a large mixing bowl, combine shredded chicken, cooked spaghetti, condensed cream of chicken soup, chopped bell peppers, paprika, cayenne pepper, garlic powder, and half of the shredded cheddar cheese. Mix until thoroughly blended.

Step 05

Assemble and Bake: Transfer the mixture into the prepared casserole dish. Sprinkle remaining cheddar cheese over the top. Bake for 25–30 minutes until bubbly and golden brown.

Step 06

Finish and Serve: Allow the casserole to rest for 5 minutes, then garnish with sliced green onions before serving.

Necessary tools

  • Casserole dish
  • Large pot
  • Mixing bowl
  • Forks (for shredding chicken)

Allergy information

Review each ingredient for potential allergens and consult with healthcare providers if you're uncertain.
  • Contains milk and wheat (gluten); also includes potential allergens from processed soup.

Nutrition facts (per portion)

These values are estimates only and shouldn't replace professional medical guidance.
  • Calories: 380
  • Fat: 18 g
  • Carbohydrates: 36 g
  • Protein: 24 g